HVAC Engineering System Design

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  • View profile for Dr. Shishir K. Srivastava

    Global Citizenship Educator (GCED) | Founder & CEO, Unifusion Consultants | Founder, GCSN | School Leadership Mentor | Peace & Sustainability Advocate | Author | Speaker

    9,707 followers

    Vietnam just turned agricultural waste into climate control — and it’s brilliant. While many countries spend millions on air-conditioning classrooms, educators in Vietnam found a smarter solution right under their feet. Their secret weapon? Coconut husks — the fibrous waste usually discarded after harvesting. These husks are now being transformed into natural insulation panels that keep classrooms up to 6°C cooler without using a single unit of electricity. The science is elegantly simple: the fibers trap air, reduce heat transfer, and improve ventilation — delivering passive cooling that’s affordable, scalable, and climate-friendly. This innovation shows that effective climate solutions don’t always require complex technology. Sometimes, they come from rethinking waste as a resource. Vietnam’s approach is a powerful reminder: sustainability works best when it’s local, low-cost, and rooted in nature. #ClimateInnovation #PassiveCooling #SustainableEducation #CircularEconomy #VietnamInnovation #LowEnergySolutions #GreenDesign #GlobalCitizenship

  • View profile for Ravi Shankar Kumar

    Sr. Vice President - Head MEP with Ireo Private Limited l MEP Design Coordination and Execution I Construction I Real Estate I Ex- Vatika I Ex - Emaar I Ex - Orris I Ex - Conscient l Ex- Krisumi I EX- Pearl

    71,200 followers

    HVAC MEP Thumb Rules & Formulas (With Examples) 1. Heat Load Calculation Formula: Q = Area (sq.ft) x Heat Load Factor (BTU/hr per sq.ft) Example: 500 sq.ft office: Q = 500 x 30 = 15,000 BTU/hr → TR = 1.25 2. CFM Calculation Formula: CFM = Sensible Heat (BTU/hr) / (1.08 x Delta T) Example: 12,000 BTU/hr, Delta T = 20°F → CFM = 556 3. AHU / FCU Sizing Rule: 1 TR = 400 CFM 2 TR → Airflow = 800 CFM 4. Duct Sizing Velocity Limits: Main: 1400–1800 FPM 800 CFM @ 1000 FPM → 0.8 sq.ft ≈ 14"x10" 5. Chilled Water Flow Rate Formula: GPM = BTU/hr / (500 x Delta T) Example: 24,000 BTU/hr → GPM = 4.8 6. Pipe Sizing 1" pipe: 8–12 GPM 2" pipe: 30–40 GPM 35 GPM → Use 2" 7. Chiller Sizing Formula: TR = BTU/hr / 12,000 Example: 60,000 BTU/hr → 5 TR 8. Cooling Tower Sizing Rule: Heat Rejection = 1.25 x Load 10 TR → Tower = 12.5 TR 9. Pump Head Calculation Formula: Power (kW) = (Q x H x 9.81) / (Efficiency x 1000) Example: Q = 5 L/s, H = 20m, Efficiency = 0.75 Power = 1.31 kW 10. Fresh Air Requirement Office: 15–20 CFM/person 20 people → 300 CFM 11. Electrical Load 1 TR = 1.25 kW 10 TR → 12.5 kW 12. Condenser Water Flow 3 GPM per TR 15 TR → 45 GPM 13. Return Air Duct 2 sq.in. per CFM 600 CFM → 1200 sq.in. ≈ 10"x12" 14. VRV / VRF Capacity 1 HP = 0.8 TR COP = 3.5–4.5 15. Chilled Water Pipe Velocity Chilled Water: 3–12 ft/s Condenser: 6–9 ft/s HVAC Design for Clean Rooms – Hospitals & Pharma 1. Clean Room Classifications (ISO & GMP) Classification Max. Particles ≥0.5µm / m³ Typical Use ISO 5 / Class 100 3,520 OT, IV Room ISO 7 / Class 10,000 352,000 Compounding Area ISO 8 / Class 100,000 3,520,000 Packing Area 2. Air Changes Per Hour (ACH) Room Type Recommended ACH Operation Theater (OT) 20–25 ICU / NICU 15–20 Cleanrooms ISO 7 60–90 Cleanrooms ISO 8 15–20 Example: Room Volume = 5m x 5m x 3m = 75 m³ ACH = 25 → Airflow = (25 x 75)/60 = 31.25 CMM ≈ 1100 CFM 3. HEPA Filter Design HEPA Efficiency: ≥99.97% @ 0.3µm 1 HEPA filter (24"x24") handles ~500 CFM OT needing 1000 CFM → Use 2 filters 4. Room Pressure Differential Area Type Pressure Difference OT vs Corridor +10 to +15 Pa ICU vs Corridor +5 to +10 Pa Isolation Room -10 to -15 Pa 5. Laminar Airflow (LAF) Velocity: 90 ± 20 ft/min (0.45 ± 0.05 m/s) Area: ~9ft x 6ft above OT table 6. Humidity & Temperature Control Area Temp (°C) RH (%) OT 21–24 50–60 ICU / Patient Room 23–26 30–60 Pharma Cleanroom 20–22 45–55 7. Exhaust Systems Negative pressure rooms require 100% exhaust Use bag-in bag-out filters for hazardous exhausts 8. Validation Parameters Air velocity test Smoke pattern (laminarity) Particle count HEPA integrity test Example: Small OT Room (ISO 7 / GMP Grade B) Parameter Value Room Volume 6m x 5m x 3m = 90 m³ ACH 25 → Airflow = 1325 CFM HEPA Filters 3 (500 CFM each) Pressure +15 Pa Temp/RH 22°C / 55%

  • View profile for Dr Ahmad Sabirin Arshad

    Group Managing Director @ Boustead Holdings Berhad , 100M Impressions, Favikon Top 50 Content Creators 2025; Top 100 CEOs to Follow on LinkedIn 2024; Top 10 CEOs to Follow on LinkedIn 2023, 2022

    162,768 followers

    The Netherlands is exploring innovative ways to make data centers more energy-efficient by developing floating data centers that use canal water for cooling. Data centers require enormous amounts of electricity, not only to power servers but also to cool the equipment and prevent overheating. Traditional data centers rely heavily on air-conditioning systems, which consume significant energy and increase operational costs. To reduce this energy demand, engineers in the Netherlands have proposed floating server facilities that use nearby water sources such as canals, lakes, or ports for natural cooling. The concept works by circulating water from the canal through specialized heat exchangers. The water absorbs heat generated by the servers and carries it away, reducing the need for energy-intensive cooling equipment. This method can significantly lower energy consumption and reduce the environmental footprint of large-scale computing infrastructure. Floating data centers also offer additional benefits such as modular construction, flexible deployment, and efficient land use in densely populated cities. The Netherlands, known for its extensive canal networks and expertise in water engineering, provides an ideal environment for testing this approach. As global demand for cloud computing, artificial intelligence, and digital services continues to rise, innovative cooling solutions like floating data centers could play a major role in making the world’s digital infrastructure more sustainable and energy-efficient. #DataCenterInnovation #GreenTechnology #SustainableComputing #TechInfrastructure #FutureEngineering

  • View profile for Basheer Nazmy

    MEP Technical Manager @ Absal Paul Contracting

    17,919 followers

    🌬️Generator Room Ventilation & Exhaust Design for MEP Professionals ⚙️ 🔹 1️⃣ Importance of Ventilation Proper ventilation serves three vital functions: • 🌡️ Removes heat emitted by generator and exhaust systems. • 💨 Supplies combustion air needed for engine efficiency. • 🚫 Eliminates hazardous fumes, protecting maintenance personnel. Poor ventilation risks overheating, performance loss, and hazardous working conditions. 🔹 2️⃣ Calculating Ventilation Airflow Follow this expert sequence for accurate ventilation airflow: ✅ Step 1: Calculate heat from generator (kW). ✅ Step 2: Estimate heat from exhaust piping/mufflers. Use ~30% of uninsulated values for insulated pipes. ✅ Step 3: Consider additional heat sources (e.g., other machinery). ✅ Step 4: Sum total heat load (Qₜₒₜ). ✅ Step 5: Define max allowable temp rise above outdoor conditions (typically max room temp ~50°C). ✅ Step 6: Use airflow equation: 📌 Vₐᵢᵣ = Qₜₒₜ / (Cₚ × ρ × ΔT) Where: • Vₐᵢᵣ = Required ventilation airflow (m³/s) • Qₜₒₜ = Total heat load (kW) • Cₚ = Specific heat of air (1.005 kJ/kg·°C) • ρ = Air density (1.2 kg/m³) • ΔT = Acceptable temp rise (°C) ✅ Step 7: Include combustion airflow from engine specifications. ✅ Step 8: Adjust airflow for altitude: 📌 Vₐdⱼ = Vₜₒₜ × [ (Altitude(m)/305 × 0.03) + 1 ] 🔹 3️⃣ Fan and Louver Selection Select fans considering factory-installed radiator fan capabilities: • ⚙️ If radiator airflow ≥ adjusted airflow (Vₐdⱼ), auxiliary fan not required. • 🔄 If less, size auxiliary fan to cover shortfall. • 🔧 If no radiator fan, total airflow is from auxiliary fans. Choose louvers based on airflow and louver guidelines to ensure optimal distribution and airflow patterns. 🔹 4️⃣ Exhaust System Essentials Exhaust systems safely remove fumes and control noise. Key components include: • 🔇 Mufflers (industrial: 12-18 dB, residential: 18-25 dB, critical: 25-35 dB reductions). • 🛠️ Exhaust pipes and fittings sized correctly to manage back pressure. 🔹 5️⃣ Exhaust Back Pressure Calculation • Identify max allowable back pressure from generator specs. • Calculate gas velocity: 📌 Velocity = Gas Flow / Muffler Cross-sectional Area • Use charts or software tools to estimate muffler-induced back pressure. • Verify total back pressure is below allowable limits. If exceeded, install auxiliary fans. 🔹 6️⃣ Good Practices & Standards • 🔥 Insulate exhaust pipes to minimize heat radiation and prevent accidental contact. • 📐 Slope exhaust pipes downward to drain condensate effectively. • 🌬️ Ensure intake and exhaust are positioned on opposite walls to maximize airflow. • 📏 Maintain adequate spacing around louvers—ideally, three times louver height. • 🎯 Regularly drain condensate from silencer traps to maintain system efficiency. By adhering to these structured, engineering-driven guidelines, you’ll ensure generator rooms operate safely, efficiently, and reliably. 📈🏢 #basheernazmy

  • View profile for Mouhanad ALOUWAYED

    MEP Consultant Engineer

    1,291 followers

    Understanding ASHRAE Design Percentiles: 0.4%, 1%, 2% If you’ve worked with ASHRAE climate data, you might have seen numbers like: 40 °C → 0.4% 38.3 °C → 1% 36.8 °C → 2% But what do they actually mean for your HVAC or refrigeration system? ✅ Percentiles describe how often a temperature is exceeded in a year: 40 °C → 0.4% Outdoor temperature is higher than 40 °C for only 0.4% of the year (~35 hours/year). This also means the system covers 99.6% of the annual hours at 40 °C. 38.3 °C → 1% Outdoor temperature is higher than 38.3 °C for only 1% of the year (~88 hours/year). System covers 99% of the year at 38.3 °C. 36.8 °C → 2% Outdoor temperature is higher than 36.8 °C for only 2% of the year (~175 hours/year). System covers 98% of the year at 36.8 °C. 💡 Important nuance: These hours are not spread evenly across the year. Most occur in the hottest months. That means: In a 4-month summer (~2880 hours), the 1% hottest hours represent ~3% of summer hours. In the hottest month (~720 hours), they could represent ~12% of that month’s hours. 📌 How to use this in design: Critical systems (data centers, hospitals) → use 0.4%. Typical commercial buildings → 1%. Non-critical or cost-sensitive projects → 2%. ASHRAE percentiles aren’t arbitrary—they tell you how often your system will face peak loads. Understanding them helps you size equipment wisely, avoid oversizing, and plan for reliability where it matters most.

  • View profile for Pawel Wargocki

    Academic teacher, scientist, industry consultant, IAQ expert. Mechanical engineer by education. Expertise in environmental psychology, physiology, exposure monitoring. Co-Chair, Global Commission on Healthy Indoor Air.

    6,010 followers

    We spend one third of our lives sleeping, and this time is crucial for our health, well-being, and cognitive performance the next day. Thanks to ASHRAE funding, we completed a research project (ASHRAE 1837-RP) that has provided new information on the importance of bedroom air quality and ventilation for sleep quality. A paper summarizing the numerous experiments we performed in two parts of the world (Europe and China) has just been published:https://lnkd.in/d6gSgsec. The most important finding is that existing ventilation practice in bedrooms must be changed, and that rectifying this will have consequences for design and residential ventilation standards in dwellings, student dormitories, and hotels. We recommend that bedroom ventilation should be at a level to keep the CO2 concentration emitted by bedroom occupants at 800 ppm or below. This will require much higher ventilation rates in dwellings (bedrooms) than are currently prescribed in the standards. Increased ventilation does not need to consume much more energy, but the actual challenge is how to retrofit billions of bedrooms that currently have no ventilation at all, except the possibility to open a window. We encourage more research and development in this area. To address this challenge, a research innovation network on sleep was recently initiated by @ISIAQ: https://lnkd.in/dVf2UmKV. Mizuho Akimoto Xiaojun Fan Li Lan Chandra Sekhar Shin-ichi Tanabe @David P. Wyon International Centre for Indoor Environment and Energy DTU Sustain

  • View profile for imle atif ahmed mehboob

    Environment Health & safety Specialist/Fire /DFSE/IOSH/ADIS from MSBTE/NFPA-1072-Hazmat-AW/NFPA-1072-Hazmat-OP/NFPA-1001-FF1/ NEBOSH International General certificate in occupational health and safety IG-1 and IG-2.

    3,229 followers

    Ventilation in high-rise buildings is a life-safety–critical system, and National Fire Protection Association (NFPA) provides several standards that guide how these systems are designed, installed, and operated—especially for smoke control during fires. 🔥 Key NFPA Standards for High-Rise Ventilation The most relevant codes include: NFPA 92 – primary standard for smoke management systems NFPA 101 – overall building life safety requirements NFPA 90A – HVAC system safety NFPA 72 – system integration and controls International Code Council (IBC) is often used alongside NFPA (not NFPA, but commonly integrated) 🌬️ Ventilation & Smoke Control Concept in High-Rise Towers 1. Smoke Control Objectives The system is designed to: Keep escape routes (stairs, corridors) smoke-free Limit smoke spread between floors Aid firefighting operations 2. Main Ventilation Strategies A. Pressurization Systems (Most Critical) Stairwells, elevator shafts, and refuge areas are positively pressurized Air is mechanically supplied to keep smoke out Typical NFPA 92 design targets: Pressure difference: ~0.05–0.15 in. water gauge (12–37 Pa) Doors must still be operable (not too much pressure) B. Exhaust (Smoke Extraction) Systems Removes smoke from: Fire floor Basements Atriums Uses: High-temperature rated fans Dedicated ductwork C. HVAC System Shutdown & Control Normal HVAC is automatically shut down to prevent smoke spread Fire/smoke dampers close to isolate zones Controlled through fire alarm system (NFPA 72 integration) D. Zoned Smoke Control Building divided into smoke zones Only affected zones are exhausted or controlled Prevents full-building contamination E. Natural Ventilation (Limited Use) Sometimes used in: Atriums Skylights Relies on buoyancy (stack effect), but: Less reliable than mechanical systems Often supplementary to NFPA 92 systems ⚙️ Key NFPA Design Requirements 1. System Reliability Redundant fans and power supplies Emergency power (generator-backed) 2. Activation Automatic via: Smoke detectors Sprinkler flow switches Manual firefighter override required 3. Testing & Commissioning Full-scale performance testing required (NFPA 92) Periodic inspection and maintenance 4. Temperature Ratings Fans and components must withstand: 250–300°C (482–572°F) for specified durations 🏢 Special High-Rise Considerations Stack effect (strong vertical airflow due to height) must be controlled Wind pressures affect system performance Elevator shaft smoke control is critical Refuge floors may require independent ventilation 🧠 Simple Way to Think About It In a fire: Stairs → keep clean (pressurize) Fire floor → remove smoke (exhaust) Other floors → isolate (dampers + zoning)

  • View profile for Dr. Wajid Ali

    Critical Care Physician (ICU Resident) Mechanical Ventilation | Hemodynamic Stabilization | ACLS | High-Acuity ICU | Code Blue Leader | Patient Outcomes Focused

    3,841 followers

    _Peak Inspiratory Pressure (PIP) and Plateau Pressure (Pplat):_ *Peak Inspiratory Pressure (PIP):* 1. Maximum pressure applied to the airways during inhalation. 2. Reflects the pressure required to deliver a breath. *Plateau Pressure (Pplat):* 1. Pressure measured during a brief pause (0.5-1.5 seconds) at the end of inhalation. 2. Reflects the pressure within the lungs when airflow is stopped. *Difference:* PIP measures the peak pressure during inhalation, while Pplat measures the static pressure within the lungs. *Calculation:* 1. PIP: Measured directly by the ventilator. 2. Pplat: Measured by pausing inhalation for 0.5-1.5 seconds and reading the pressure. *Significance:* 1. PIP: Evaluates airway resistance and compliance. 2. Pplat: Assesses lung stress, recruitment, and overdistension. *Monitoring Safe Lung Ventilation:* 1. PIP ≤ 30-40 cmH2O (varies depending on patient population). 2. Pplat ≤ 25-30 cmH2O (to avoid lung injury). *Complications and Management:* *High PIP (>40 cmH2O):* 1. Barotrauma (lung damage). 2. Pneumothorax. 3. Management: Reduce tidal volume, increase respiratory rate, or use pressure-controlled ventilation. *High Pplat (>30 cmH2O):* 1. Lung overdistension. 2. Volutrauma. 3. Management: Reduce tidal volume, increase PEEP, or use lung-protective ventilation strategies. *Specific Clinical Scenarios:* 1. *ARDS:* Maintain Pplat ≤ 25 cmH2O, PIP ≤ 30 cmH2O. 2. *Asthma:* PIP may be elevated due to airway resistance; monitor Pplat. 3. *COPD:* PIP may be elevated; focus on maintaining adequate ventilation. 4. *Neonatal ventilation:* Maintain PIP ≤ 20 cmH2O, Pplat ≤ 15 cmH2O. *Guidelines:* 1. American Thoracic Society (ATS). 2. European Respiratory Society (ERS). 3. Surviving Sepsis Campaign (SSC). *Key Considerations:* 1. Monitor PIP and Pplat to ensure safe ventilation. 2. Adjust ventilation settings based on patient response. 3. Consider lung-protective ventilation strategies. References: 1. Tobin et al. (2012). Principles and Practice of Mechanical Ventilation. 2. ATS/ERS/ESICM/SCCM. (2017). Mechanical Ventilation in Adult Patients. 3. SSC. (2020). Ventilatory Support in Adult Patients.

  • View profile for Ramkumar Madasamy

    HVAC Technical Authority||HVAC Specialist||Lead HVAC Engineer(HVDC/HVAC Wind Platforms,Oil and gas Platforms and Marine)||MEP Specialist-Buildings|| GATE-2005 Qualified.99.37 Percentile.All India Rank-142 (In Mechanical)

    9,336 followers

    HVAC SYSTEM DESIGN: BATTERY ROOM VENTILATION The following major points should be considered while designing the battery room ventilation/AC system design.   1) Ventilation rate/ACH: Provide the Ventilation rate/ACH as recommended in applicable codes and standards/As specified in Employer specifications/ recommended Battery Vendor. This is required to limit the gas concentration below the LEL.   Consider the float/boost/commissioning charging scenarios.   2) Cooling/ heating: If a local cooling unit (like FCU) is not provided, supply air from the central plant (AHU) should be able to provide the required cooling capacity. A duct heater in the supply duct may be required for heating mode. Note that battery life will be affected by room temperature. So the vendor recommended stringent design temperature (18-22 OC) may be required.   3) Air distribution: For efficient exhaust of released gas cross airflow pattern is required. Supply grilles should be planned at a low level on one side of the room and the exhaust duct should be planned on the opposite side of the room at a high level.   If the ceiling/deck construction forms the dead air pocket, then exhaust from these pockets should be planned   4) Pressurization: Slightly negative pressure should be maintained with respect to adjacent safe area rooms. Room PDT should be provided for pressure monitoring. An alarm should be generated upon loss of room pressure.   5) Exhaust fans and interlock with battery charging: Dedicated, Hazardous rated Redundant fans (2*100%) should be planned. Fan operation should be monitored by PDT across the fans. An interlock to inhibit the battery charging upon failure of both fans should be provided. Based on project requirements, natural ventilation is also possible. In this case, the vent area should be sized as per the procedure specified in the applicable codes/standards.   6) Material construction: Due to the corrosive nature of the evolved/released gas, stainless steel material for the construction of fans, ductwork, equipment, and inline item, the instrument is required 7) Hazardous area classification HVAC fans, instruments, etc. should be selected for the specified hazardous rating (Zone 1, IIC, T1, etc).   8) Gas-tight & relief dampers Suppose the room is provided with inert firefighting system. In that case, then gas tight motorized damper should be provided in all the perimeter motorized dampers and closing timing should be planned for quick closure considering the delay time of gas release. A gaseous relief duct system should be planned if the room structure cannot withstand the overpressure due to inert gas release.     9) Ductwork routing: Discharge the exhaust directly to outdoors. Avoid routing the ductwork through other “SAFE AREA” rooms. If routing is unavoidable, use welded ductwork (instead of lock-formed ductwork).

  • View profile for Eng. Ashish Kumar Patil

    HVAC Senior Project Engineer | Mechanical Engineering | Certified Marketing Insider | HVACR Solutions

    27,528 followers

    #HVAC MEP Thumb Rules & Formulas (With Examples) 1. Heat Load Calculation Formula: Q = Area (sq.ft) x Heat Load Factor (BTU/hr per sq.ft) Example: 500 sq.ft office: Q = 500 x 30 = 15,000 BTU/hr → TR = 1.25 2. CFM Calculation Formula: CFM = Sensible Heat (BTU/hr) / (1.08 x Delta T) Example: 12,000 BTU/hr, Delta T = 20°F → CFM = 556 3. AHU / FCU Sizing Rule: 1 TR = 400 CFM 2 TR → Airflow = 800 CFM 4. Duct Sizing Velocity Limits: Main: 1400–1800 FPM 800 CFM @ 1000 FPM → 0.8 sq.ft ≈ 14"x10" 5. Chilled Water Flow Rate Formula: GPM = BTU/hr / (500 x Delta T) Example: 24,000 BTU/hr → GPM = 4.8 6. Pipe Sizing 1" pipe: 8–12 GPM 2" pipe: 30–40 GPM 35 GPM → Use 2" 7. Chiller Sizing Formula: TR = BTU/hr / 12,000 Example: 60,000 BTU/hr → 5 TR 8. Cooling Tower Sizing Rule: Heat Rejection = 1.25 x Load 10 TR → Tower = 12.5 TR 9. Pump Head Calculation Formula: Power (kW) = (Q x H x 9.81) / (Efficiency x 1000) Example: Q = 5 L/s, H = 20m, Efficiency = 0.75 Power = 1.31 kW 10. Fresh Air Requirement Office: 15–20 CFM/person 20 people → 300 CFM 11. Electrical Load 1 TR = 1.25 kW 10 TR → 12.5 kW 12. Condenser Water Flow 3 GPM per TR 15 TR → 45 GPM 13. Return Air Duct 2 sq.in. per CFM 600 CFM → 1200 sq.in. ≈ 10"x12" 14. VRV / VRF Capacity 1 HP = 0.8 TR COP = 3.5–4.5 15. Chilled Water Pipe Velocity Chilled Water: 3–12 ft/s Condenser: 6–9 ft/s HVAC Design for Clean Rooms – Hospitals & Pharma 1. Clean Room Classifications (ISO & GMP) Classification Max. Particles ≥0.5µm / m³ Typical Use ISO 5 / Class 100 3,520 OT, IV Room ISO 7 / Class 10,000 352,000 Compounding Area ISO 8 / Class 100,000 3,520,000 Packing Area 2. Air Changes Per Hour (ACPH) Room Type Recommended ACPH Operation Theater (OT) 20–25 ICU / NICU 15–20 Cleanrooms ISO 7 60–90 Cleanrooms ISO 8 15–20 Example: Room Volume = 5m x 5m x 3m = 75 m³ ACH = 25 → Airflow = (25 x 75)/60 = 31.25 CMM ≈ 1100 CFM 3. HEPA Filter Design HEPA Efficiency: ≥99.97% @ 0.3µm 1 HEPA filter (24"x24") handles ~500 CFM OT needing 1000 CFM → Use 2 filters 4. Room Pressure Differential Area Type Pressure Difference OT vs Corridor +10 to +15 Pa ICU vs Corridor +5 to +10 Pa Isolation Room -10 to -15 Pa 5. Laminar Airflow (LAF) Velocity: 90 ± 20 ft/min (0.45 ± 0.05 m/s) Area: ~9ft x 6ft above OT table 6. Humidity & Temperature Control Area Temp (°C) RH (%) OT 21–24 50–60 ICU / Patient Room 23–26 30–60 Pharma Cleanroom 20–22 45–55 7. Exhaust Systems Negative pressure rooms require 100% exhaust Use bag-in bag-out filters for hazardous exhausts 8. Validation Parameters Air velocity test Smoke pattern (laminarity) Particle count HEPA integrity test Example: Small OT Room (ISO 7 / GMP Grade B) Parameter Value Room Volume 6m x 5m x 3m = 90 m³ ACH 25 → Airflow = 1325 CFM HEPA Filters 3 (500 CFM each) Pressure +15 Pa Temp/RH 22°C / 55% N.B (Collected)

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