New York, New York, United States
909 followers 500+ connections

Join to view profile

About

Software Engineer
Ex-LinkedIn Staff SWE
Ex-Amazon AWS SDE II

M.S. Computer…

Activity

Join now to see all activity

Experience & Education

  • Harmonic

View Nick’s full experience

See their title, tenure and more.

or

By clicking Continue to join or sign in, you agree to LinkedIn’s User Agreement, Privacy Policy, and Cookie Policy.

Volunteer Experience

Publications

  • Activation of Subthalamic Nucleus Stop Circuit Disrupts Cognitive Performance

    eNeuro

    Much evidence supports a fundamental role for the subthalamic nucleus (STN) in rapidly stopping behavior when a stop signal or surprising event occurs, but the extent to which the STN may be involved in stopping cognitive processes is less clear. Here, we used an optogenetic approach to control STN activity in a delayed-match-to-position (DMTP) task where mice had to recall a response location after a delay. We first demonstrated that a surprising event impaired performance by both slowing the…

    Much evidence supports a fundamental role for the subthalamic nucleus (STN) in rapidly stopping behavior when a stop signal or surprising event occurs, but the extent to which the STN may be involved in stopping cognitive processes is less clear. Here, we used an optogenetic approach to control STN activity in a delayed-match-to-position (DMTP) task where mice had to recall a response location after a delay. We first demonstrated that a surprising event impaired performance by both slowing the latency to respond and increasing the rate of errors. We next showed that these effects could be mimicked by brief optogenetic activation of the STN. Further, inhibiting STN during surprise blocked surprise-induced slowing, although without changing surprise-induced errors. These data are consistent with the hypothesis that STN is recruited by surprise to slow responding and that this can also interrupt cognitive processes. Under normal conditions STN-mediated stopping of behavior may slow or stop ongoing cognition to facilitate cognitive reorienting and adaptive responses to unexpected sensory information, but when malfunctioning, it could produce pathologies related to over-rigidity or increased distractibility.

    See publication
  • Long-read Amplicon Denoising

    Oxford Academic - Nucleic Acids Research

    Long-read next generation amplicon sequencing shows promise for studying complete genes or genomes from complex and diverse populations. Current long-read sequencing technologies have challenging error profiles, hindering data processing and incorporation into downstream analyses. Here we consider the problem of how to reconstruct, free of sequencing error, the true sequence variants and their associated frequencies. Called "amplicon denoising", this problem has been extensively studied for…

    Long-read next generation amplicon sequencing shows promise for studying complete genes or genomes from complex and diverse populations. Current long-read sequencing technologies have challenging error profiles, hindering data processing and incorporation into downstream analyses. Here we consider the problem of how to reconstruct, free of sequencing error, the true sequence variants and their associated frequencies. Called "amplicon denoising", this problem has been extensively studied for short-read sequencing technologies, but current solutions do not appear to generalize well to long reads with high indel error rates. We introduce two methods: one that runs nearly instantly and is very accurate for medium length reads (here ~2.6kb) and high template coverage, and another, slower method that is more robust when reads are very long or coverage is lower. On one real dataset with ground truth, and on a number of simulated datasets, we compare our two approaches to each other and to existing algorithms. We outperform all tested methods in accuracy, with competitive run times even for our slower method. Fast Amplicon Denoising (FAD) and Robust Amplicon Denoising (RAD) are implemented purely in the Julia scientific computing language, and are hereby released along with a complete toolkit of functions that allow long-read amplicon sequence analysis pipelines to be constructed in pure Julia. Further, we make available a webserver to dramatically simplify the processing of long-read PacBio sequences.

    See publication

Courses

  • Advanced Bioinformatics Laboratory

    CSE 185

  • Advanced Data Structures

    CSE 100

  • Biochemical Energetics and Metabolism

    CHEM 114B

  • Biochemical Structure and Function

    CHEM 114A

  • Biological Data Analysis

    CSE 182

  • Calculus II-III

    MATH 20B, MATH 20C

  • Computational Linguistics

    LIGN 165

  • Data Structures

    CSE 12

  • Design and Analysis of Algorithms

    CSE 101

  • Discrete Mathematics

    CSE 20

  • General Chemistry I-III

    CHEM 6A, CHEM 6B, CHEM 6C

  • Introduction to Object-Oriented Programming

    CSE 11

  • Introduction to Programming (C)

    CSE 5A

  • Knowledge-Based Artificial Intelligence

    CS 7637

  • Mathematics for Algorithms and Systems

    CSE 21

  • Molecular Sequence Analysis

    CSE 181

  • Network Security

    CS 6262

  • Organic Chemistry

    CHEM 40A, 40B, 40C

  • Physical Biochemistry I: Thermodynamics and Kinetics of Biomolecules

    CHEM 126A

  • Physics—Mechanics

    PHYSICS 2A

  • Probability and Statistics for Bioinformatics

    MATH 186

  • Software Development Process

    CS 6300

  • Software Tools and Techniques Laboratory

    CSE 15L

Projects

  • Study Groups

    -

    Built a social networking app that allows students (who sign up with a .edu email) to connect with other students at their institution to find study groups. This is achieved by searching by class names and codes, filtering results with a "like/save" feature, and allowing students to create their own study groups. The app allows students to set a time, date, and location for their class study sessions. Other students at the same school are able to view these groups and attend sessions with the…

    Built a social networking app that allows students (who sign up with a .edu email) to connect with other students at their institution to find study groups. This is achieved by searching by class names and codes, filtering results with a "like/save" feature, and allowing students to create their own study groups. The app allows students to set a time, date, and location for their class study sessions. Other students at the same school are able to view these groups and attend sessions with the information provided.

    Skills used/Aquired
    - Firebase backend integration
    - Full Stack React Native
    - Database field control
    - User flow/control with specific accounts
    - Redux and API keys

    Google Play Store:
    //Currently fixing to meet new compliance requirements by Google

    iOS App Store:
    https://itunes.apple.com/us/app/study-groups/id1435273067?mt=8

    See project
  • Tutoring Push Notifications — UC San Diego Mobile Application

    -

    - Worked on a team that designed a full stack API to notify students of upcoming tutoring sessions for their classes
    - Client - Server data structures via REST API and reducers

  • React-Native Dating App Framework

    -

    The built the frontend framework for a dating app centered around college students in React Native. I learned and mastered various techniques such as state control, frontend/backend integration, user flow, and object oriented component design. The mechanism is similar to that of Tinder and other various dating apps.

    See project

Languages

  • English

    Native or bilingual proficiency

  • Spanish

    Limited working proficiency

Recommendations received

More activity by Nick

View Nick’s full profile

  • See who you know in common
  • Get introduced
  • Contact Nick directly
Join to view full profile

Other similar profiles

Explore top content on LinkedIn

Find curated posts and insights for relevant topics all in one place.

View top content

Add new skills with these courses